National Centre for Biological Sciences, Bengaluru

  •   National Centre for Biological Sciences
    Tata Institute of Fundamental Research
    Bellary Road, Bengaluru
    Karnataka - 560065, India
  •  91 80 23666001
  •   Website

Principal Investigator: Prof. Raghu Padinjat

Co-Investigators: Dr. Sabarinathan Radhakrishnan

Role of the Institution in the GenomeIndia Project: Constructing a genome-wide map of con- strained genomic regions in Indian population. Supporting genome sequencing through the NCBS NGS facility.

Accomplishments and Outcomes

We have developed a bioinformatic pipeline to identify constrained genomic regions (indicating the signals of purifying selection). The pipeline was validated using publicly available dataset such as gnomAD and GenomeAsia. Further, we have applied it to the GenomeIndia dataset (joint variant calls from 5750 samples) and currently exploring the results.