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Principal Investigator: Prof. Raghu Padinjat
Co-Investigators: Dr. Sabarinathan Radhakrishnan
Role of the Institution in the GenomeIndia Project: Constructing a genome-wide map of con- strained genomic regions in Indian population. Supporting genome sequencing through the NCBS NGS facility.
We have developed a bioinformatic pipeline to identify constrained genomic regions (indicating the signals of purifying selection). The pipeline was validated using publicly available dataset such as gnomAD and GenomeAsia. Further, we have applied it to the GenomeIndia dataset (joint variant calls from 5750 samples) and currently exploring the results.
