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Principal Investigator: Prof. Bratati Kahali
Contributors: Prof. Vijayalakshmi Ravindranath (Founder Director, CBR), Prof. Y Narahari (National Joint Co-ordinator), Prof. KVS Hari, Dr. Prathima Arvind (Project Manager), Dr. Shweta Ramdas, Dr. Khader Valli Rupanagudi, Dr. Shafeeq KSH, Jothibasu V, Krithika Subramanian, Siddhi Jani, Shreya Chakraborty, Akkshaya Rajesh, Raghvendra Agrawal, Debasrija Mondal, Mohammad Hanif KM, Vinayak H, Dr. Shobha Anilkumar, Mohan C, Rajesh G, Diwakar A, Anand Kumar, Karthik S, Ravindra V.
Role of the Institution in the GenomeIndia Project: CBR is the coordinating centre for the GenomeIndia project. CBR spearheads efforts in strategic planning and execution of the entire project. The institute has been involved in sample collection, whole genome sequencing, data processing and analysis, as well as joint genotyping for all samples. It maintains a biobank of collected DNA samples.
CBR has recruited more than 3,000 individuals from sixteen different communities for the project. They have undergone detailed sociodemographic questionnaire assessment, anthropometric measurements, and blood biochemical investigations.
CBR has formulated the best practices for sequencing and analysis protocols for the consortium for variant calling at individual genome levels, defined the thresholds for various quality check parameters, followed by optimizing the protocol for joint genotyping of >5000 individuals that would be followed for joint genotyping of 10000 individuals’ data. The downstream variant checking and analysis protocols were defined by CBR. CBR has also been actively uploading data to IBDC for use by other consortium members. The joint genotyping for 5750 individuals’ genomes spanning 69 population subgroups were executed by CBR, and in parallel by NIBMG.
CBR has received 19231 samples from all sample collection centres for biobanking. The biobanking activities at CBR were coordinated by a team led by Dr. Shobha Anil Kumar.
