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Principal Investigator: Dr. K Thangaraj, Dr. Vinay K Nandicoori
Co-Investigators: Dr. Divya Tej Sowpati, Dr. Karthik Bharadwaj Tallapaka
Contributors: Payel Mukherjee, Pratheusa Maccha, Sofia Banu, Sreelekshmi MS, Malini Nemalikanti, Tulasi Nagabandi, Valli Undamatla, Devavrat Desai, Neha Singh, Priya Pandey, G Mala, Deepak Kashyap, Mahfuj Hassan, Vasanth Kumar
Role of the Institution in the GenomeIndia Project:
We have completed sample collection from our target communities from Tamil Nadu, Andhra Pradesh, Telangana, and Uttarakhand, including critical tribes such as Chenchu in Andhra Pradesh and Tharu of Uttarakhand. The blood samples from the above were analyzed for various biochemical parameters including CRP, Liver function, Lipids, Kidney function among others. The blood samples were also sent to CBR, Bengaluru for biobanking.
Over 3200 samples, including those collected by GBRC and AIIMS-Jodhpur, were genotyped using Illumina GSA, out of which more than 2500 samples were deemed suitable for sequenced. Samples from these communities were sequenced using the Illumina NovaSeq 6000 platform. Raw data was processed to ensure they met the expected quality criteria, and sample wise variants were obtained following the DRAGEN pipeline. Sample level quality checks were performed to remove potential outliers, and those that passed the checks were taken further for population-scale joint genotyping.
