GenomeIndia, a visionary national project funded by the Department of Biotechnology,
Government of India, was launched in January 2020.Its ambitious goal is to sequence 10,000
genomes from healthy Indian individuals spanning the length and breadth of the country.
The primary aim of GenomeIndia is to construct a comprehensive catalogue of genetic variations
for India’s population that will better capture our unique diversity. This initiative is not just
about decoding our genes; it is about creating a detailed reference that encapsulates the Indian
population’s genetic makeup and enables a deeper understanding of its diversity.
The GenomeIndia project will create a precious national resource for India’s public health. This effort has the potential to revolutionise healthcare, empowering basic researchers and clinicians, leading to transformative precision interventions. GenomeIndia, therefore, is an important step towards a healthier nation.
About 1 in 1000 positions differ between any two individuals on average, resulting in diverse genetic codes. These genetic variations among individuals affect our disease risks, and also determine a person’s responses to drugs. Understanding these genetic nuances is key to deciphering people’s predispositions to certain diseases and designing effective treatments for these. A reference set of genetic variants highlighting uniqueness of the Indian population will lead to a better understanding of the nature of diseases. It will open doors to specific interventions essential for diverseethnic groups, thereby paving the way for more targeted and effective healthcare solutions.
The instruction manual for our life, the human genome, is made up of DNA, represented by four letters A, C, G, and T. This genetic script, making up the human genome, extends across a staggering three billion such letters. Housed within the cells of our body, our genomes manifest as 23 pairs of chromosomes. In the intricate phenomenon of heredity, we inherit our genomes from our parents. Half our DNA is from our mothers, and half is from our fathers. This genetic inheritance orchestrates the very essence of our being.